The combination of Oxiracetam and CDP-Choline will subtly increase one’s ability to stay focused and retain information at a higher rate. However on highly demanding days subtle simply isn’t going to cut it. Adding Vinpocetine and Caffeine, will provide an extra boost that will allow you to cope with more demanding days. Vinpocetine is a semisynthetic derivative of a compound called Vincamine, which is naturally present in the lesser periwinkle plant. Vinpocetine seems to increase memory via various different mechanisms. It has been shown that Vinpocetine is a sodium and calcium channel inhibitor (6), and it appears that inhibiting these channels can increase memory (7). Vinpocetine also interacts with the alpha-adrenergic receptors (8), and it seems that this is in part responsible for its memory enhancing effects (9). Vinpocetine also increases blood flow in the brain(10), this is important because neurons need blood to function and thus increased blood flow could lead to increased functioning of neurons. Caffeine is a naturally occurring alkaloid found in many plant species, the most common of which being coffee and tea. Caffeine is the most commonly used stimulant in the world. It acts by blocking a family of receptors called the adenosine receptors (11). These receptors cause a myriad of effects when they are activated. One of these effects is that it makes us feel sleepy, thus blocking these receptors causes us to feel more alert (12). Caffeine also increases the amount of acetylcholine receptors and acetylcholine release in the brain (13), (14) and thus is additive to the acetylcholine effects of Oxiracetam and CDP-Choline. A handy formulation of Vinpocetine and Caffeine in gum form called Think Gum can be purchased here.
